| Disruption of cell spreading by the activation of MEK/ERK pathway is dependent on AP-1 activity. | |
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MedLine Citation:
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PMID: 20942268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that the disruption of cell spreading by v-Crk was dependent on the activation of the MEK/ERK pathway. Here we demonstrate that the activation of that pathway is sufficient to suppress cell spreading. The MEK/ERK pathway regulates the activity of various proteins including AP-1, which is a transcriptional factor composed of heterodimeric proteins. To examine whether AP-1 activity is required for the suppression of cell spreading by the activation of the MEK/ERK pathway, we expressed BATF, which is a negative regulator of AP-1. The expression of BATF clearly restored cell spreading that was suppressed by the activation of MEK/ERK pathway. In addition, a disrupted formation of stress fibers and focal adhesions by such activation was restored by the suppression of AP-1. Our results define an essential role of the MEK/ERK/AP-1 pathway in the disruption of actin cytoskeleton and cell spreading. |
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Authors:
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Feng Xu; Satoko Ito; Michinari Hamaguchi; Takeshi Senga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nagoya journal of medical science Volume: 72 ISSN: 0027-7622 ISO Abbreviation: Nagoya J Med Sci Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0412011 Medline TA: Nagoya J Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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Department of Cancer Biology, Nagoya University Graduate School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Transformed Cell Transformation, Neoplastic / metabolism* Extracellular Signal-Regulated MAP Kinases / metabolism* MAP Kinase Kinase 1 / genetics, metabolism* MAP Kinase Signaling System / physiology* Microfilaments / metabolism Rabbits Rats Transcription Factor AP-1 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factor AP-1; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2/MAP Kinase Kinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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