Document Detail


Disruption of blood-brain barrier during acute hypertension in adult and aged rats.
MedLine Citation:
PMID:  2113773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The goal of this study was to determine whether the susceptibility of the blood-brain barrier to disruption during acute hypertension is altered in aged rats. Intravital fluorescent microscopy and fluorescein-labeled albumin were used to evaluate disruption of the blood-brain barrier during acute hypertension in adult Wistar rats (6-8 mo) and aged Wistar rats (24-26 mo). Permeability of the blood-brain barrier albumin and by counting the number of microvascular leaky sites under control conditions and during acute arterial hypertension in adult and aged rats. Pressure in pial venules, which are the primary site of disruption of the blood-brain barrier during acute hypertension, and in pial arterioles was measured using a servo-null device. In adult rats, when systemic arterial pressure was increased from 124 +/- 5 (means +/- SE) to 190 +/- 5 mmHg, clearance of albumin increased from 0.10 +/- 0.05 to 1.64 +/- 0.76 X 10(-6) ml/s. In aged rats, when systemic arterial pressure was increased from 116 +/- 4 to 185 +/- 3 mmHg, clearance of albumin increased from 0.10 +/- 0.03 to 1.56 +/- 0.49 X 10(-6) ml/s. Increases in pial venular pressure and pial arteriolar pressure also were similar in adult and aged rats. Thus the findings suggest that the susceptibility of the blood-brain barrier to disruption during acute hypertension is similar in adult and aged rats.
Authors:
W G Mayhan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-02     Completed Date:  1990-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1735-8     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aging / metabolism,  physiology*
Albumins / metabolism
Animals
Arterioles / physiopathology
Blood Pressure / drug effects
Blood-Brain Barrier*
Fluorescein-5-isothiocyanate
Fluoresceins / metabolism
Hypertension / metabolism,  physiopathology*
Male
Phenylephrine / pharmacology
Pia Mater / blood supply
Rats
Rats, Inbred Strains
Thiocyanates / metabolism
Venous Pressure
Grant Support
ID/Acronym/Agency:
HL-02124/HL/NHLBI NIH HHS; HL-40781/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Fluoresceins; 0/Thiocyanates; 3326-32-7/Fluorescein-5-isothiocyanate; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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