Document Detail

Disruption of the behavioral satiety sequence by simmondsin.
MedLine Citation:
PMID:  19501769     Owner:  NLM     Status:  MEDLINE    
Simmondsin, a cyanoglycoside from jojoba meal, reduces food intake after oral administration. To diagnose if it acts by inducing satiation or by creating abnormal physiological effects, an observational study was undertaken to investigate the effects of simmondsin on feeding and other behaviors. Particular attention was paid to the behavioral sequence associated with satiety (BSS). At first contact, simmondsin non-significantly reduced food intake by 17% and had little effect on feeding and associated behaviors. The behavioral structure was preserved and a small shift of the onset of resting to the left was observed, suggesting a small satiative action of simmondsin at first contact. Simmondsin given for the second time caused a more pronounced food intake reduction of 52% due to a reduction in eating duration, mean bout intake and mean bout length, and to an increase in latency to eat. At second contact, simmondsin caused a strong switching in active behaviors, disrupting the BSS. The simmondsin-induced hyperactivity suggests that simmondsin produces aversiveness with second contact. Our results indicate that simmondsin exerts multiple effects. It probably facilitates a small natural process of satiation/satiety at first contact, but creates abnormal physiological effects resulting in aversive reactions from second contact on.
Sylvia Lievens; Isabelle Verbaeys; Gerda Flo; Rudy Briers; Eddy Decuypere; Marnix Cokelaere
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-28
Journal Detail:
Title:  Appetite     Volume:  52     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  703-10     Citation Subset:  IM    
Interdisciplinary Research Centre, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium.
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MeSH Terms
Acetonitriles / adverse effects,  pharmacology*
Appetite Depressants / adverse effects,  pharmacology*
Behavior, Animal / drug effects*,  physiology
Cyclohexanes / adverse effects,  pharmacology*
Eating / drug effects
Energy Intake
Feeding Behavior / drug effects*,  physiology
Glucosides / adverse effects,  pharmacology*
Random Allocation
Rats, Wistar
Satiation / drug effects*,  physiology
Reg. No./Substance:
0/Acetonitriles; 0/Appetite Depressants; 0/Cyclohexanes; 0/Glucosides; 51771-52-9/simmondsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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