Document Detail

Disrupting proton dynamics and energy metabolism for cancer therapy.
MedLine Citation:
PMID:  23969692     Owner:  NLM     Status:  In-Data-Review    
Intense interest in the 'Warburg effect' has been revived by the discovery that hypoxia-inducible factor 1 (HIF1) reprogrammes pyruvate oxidation to lactic acid conversion; lactic acid is the end product of fermentative glycolysis. The most aggressive and invasive cancers, which are often hypoxic, rely on exacerbated glycolysis to meet the increased demand for ATP and biosynthetic precursors and also rely on robust pH-regulating systems to combat the excessive generation of lactic and carbonic acids. In this Review, we present the key pH-regulating systems and synthesize recent advances in strategies that combine the disruption of pH control with bioenergetic mechanisms. We discuss the possibility of exploiting, in rapidly growing tumours, acute cell death by 'metabolic catastrophe'.
Scott K Parks; Johanna Chiche; Jacques Pouysségur
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature reviews. Cancer     Volume:  13     ISSN:  1474-1768     ISO Abbreviation:  Nat. Rev. Cancer     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124168     Medline TA:  Nat Rev Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-23     Citation Subset:  IM    
Institute for Research on Cancer and Aging of Nice (IRCAN), Equipe Labellisée LNCC, University of Nice-Sophia Antipolis, Centre National de la Recherche Scientifique, INSERM, Centre A. Lacassagne, Nice 06189, France.
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