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Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromasts.
MedLine Citation:
PMID:  23381351     Owner:  NLM     Status:  In-Data-Review    
Zebrafish neuromast is an ideal model for investigating hair cell (HC) death and regeneration following ototoxic insults. HC undergoes rapid and robust replacement in larval zebrafish after neomycin damage. However, the origin of new HCs remains unclear. Our data showed that asymmetric cell division was involved in the process of HC regeneration in zebrafish lateral line neuromasts. Furthermore, a small molecule RRD251, which disrupted the physical interaction between RB and Raf-1 and then blocked the phosphorylation of Rb, could have inhibited the HC regeneration from supporting cell proliferation. Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous HC regeneration in zebrafish.
Qin Lin; Wenyan Li; Yan Chen; Shan Sun; Huawei Li
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  24     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  190-5     Citation Subset:  IM    
aDepartment of Otolaryngology, Eye and ENT Hospital bInstitutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
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