Document Detail


Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system.
MedLine Citation:
PMID:  24712987     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.
Authors:
Andrew D Randall; Mai Kurihara; Nicholas J Brandon; Jon T Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  39     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1068-73     Citation Subset:  IM    
Copyright Information:
© 2014 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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