Document Detail

MedLine Citation:
PMID:  18474207     Owner:  NLM     Status:  MEDLINE    
Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the work that led up to this discovery and the evidence that it is important in the wider population with schizophrenia and affective disorders. We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene.
Walter J Muir; Benjamin S Pickard; Douglas H R Blackwood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current psychiatry reports     Volume:  10     ISSN:  1535-1645     ISO Abbreviation:  Curr Psychiatry Rep     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-08-20     Revised Date:  2008-09-19    
Medline Journal Info:
Nlm Unique ID:  100888960     Medline TA:  Curr Psychiatry Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-7     Citation Subset:  IM    
Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland EH10 5HF, United Kingdom.
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MeSH Terms
Bipolar Disorder / genetics
Chromosome Aberrations*
Chromosome Breakage*
Chromosome Mapping
DNA Mutational Analysis
Depressive Disorder, Major / genetics
Genetic Markers / genetics*
Heterozygote Detection
Lod Score
Mice, Knockout
Multifactorial Inheritance
Nerve Tissue Proteins / genetics*
Psychotic Disorders / diagnosis,  genetics
Risk Factors
Schizophrenia / genetics*
Translocation, Genetic
Reg. No./Substance:
0/DISC1 protein, human; 0/Genetic Markers; 0/Nerve Tissue Proteins

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