Document Detail


Disproportionate hypertrophy of the interventricular septum and its regression in Cushing's syndrome. Report of three cases.
MedLine Citation:
PMID:  1535248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three patients of Cushing's syndrome with severe disproportionate hypertrophy of the interventricular septum are reported. All three underwent adrenalectomy and the diagnosis of Cushing's syndrome was confirmed by the presence of adrenal adenoma. All three showed hypertension before the adrenalectomy and two remained hypertensive following adrenalectomy. Before the operations the electrocardiograms revealed inverted T waves in broad leads, and mechanocardiogram systolic and diastolic dysfunction. After the adrenalectomies, abnormal findings on electrocardiograms were normalized and septal hypertrophy was completely regressed. It appears that not only high aortic pressure but also excessive plasma cortisol may be an etiologic factor of the left ventricular hypertrophy in Cushing's syndrome.
Authors:
N Sugihara; M Shimizu; K Shimizu; H Ino; I Miyamori; H Nakabayashi; R Takeda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  31     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-07-24     Completed Date:  1992-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  407-13     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy
Adult
Cardiomegaly / complications*,  etiology,  pathology
Cushing Syndrome / complications*,  physiopathology,  surgery
Female
Heart Septum / pathology*
Humans
Hydrocortisone / blood
Hypertension / complications,  physiopathology
Hypertrophy
Male
Middle Aged
Chemical
Reg. No./Substance:
50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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