Document Detail


Disposition of salicylazosulfapyridine (Azulfidine) and metabolites in human breast milk.
MedLine Citation:
PMID:  6108198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A nursing mother with ulcerative colitis was treated with salicylazosulfapyridine (SASP, Azulfidine). Multiple milk samples were collected over a 2-month period. Maternal plasma, saliva, urine and nursing infant's urine were collected. All fluids were analyzed for SASP and its metabolites. Milk did not contain SASP or its 5-amino salicylate component. Sulfapyridine (SP) and its metabolites were present in milk; the SP level was fairly constant at 3--6 micrograms/ml. The milk/saliva ratio for SP was 0.81; the milk/plasma ratio for SP was 0.60 and 0.63. Assuming an average milk concentration of 5 micrograms/ml of SP, the estimated 24-hour secretion (800 cm3 milk) would be approximately 4 mg or 0.3% of maternal dose of SP in the form of SASP. The levels of SP and metabolites determined in random urine samples from the infant were 3--4 micrograms/ml or a 24-hour excretion of 1.2--1.6 mg (30--40% of the total dose in milk). This exposure did not seem hazardous to this infant.
Authors:
C M Berlin; S J Yaffe
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  1     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1980  
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Breast Feeding
Female
Humans
Infant
Milk, Human / metabolism*
Sulfapyridine / metabolism
Sulfasalazine / metabolism*
Chemical
Reg. No./Substance:
144-83-2/Sulfapyridine; 599-79-1/Sulfasalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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