| Disposition of mesalazine from mesalazine-delivering drugs in patients with inflammatory bowel disease, with and without diarrhoea. | |
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MedLine Citation:
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PMID: 1359629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The disposition of mesalazine from the azo compounds sulphasalazine and olsalazine (Dipentum) and from the slow-release mesalazine drugs Pentasa, Asacol, and Salofalk was studied in 20 patients with inflammatory bowel disease. Ten of them had diarrhoea, and 10 had normal stools. On the last 2 days of a 7-day maintenance treatment with each of the study drugs urine and faeces were collected for determination of mesalazine, acetyl-mesalazine, and unsplit azo compound. In patients with and without diarrhoea the urinary and the faecal excretion of acetyl-mesalazine was lowest during treatment with olsalazine. The proportion of acetyl-mesalazine in faeces was highest during treatment with Pentasa in both groups. The presence of diarrhoea was associated with a decrease in the proportion of acetyl-mesalazine in faeces during treatment with all drugs, not significant only for Pentasa. The proportion of unsplit azo compound in faeces increased in the case of diarrhoea to almost 50%. It is concluded that in patients with inflammatory bowel disease diarrhoea substantially influences the disposition from all these drugs except Pentasa. |
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Authors:
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M C Rijk; A van Schaik; J H van Tongeren |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 27 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-12-01 Completed Date: 1992-12-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 863-8 Citation Subset: IM |
Affiliation:
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Dept. of Gastrointestinal and Liver Diseases, University Hospital Nijmegen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aminosalicylic Acids / chemistry, pharmacokinetics*, therapeutic use*, urine Delayed-Action Preparations / standards Diarrhea / etiology* Drug Carriers Feces / chemistry Female Gastrointestinal Transit Humans Inflammatory Bowel Diseases / complications, drug therapy*, urine Male Mesalamine Middle Aged Sulfasalazine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Aminosalicylic Acids; 0/Delayed-Action Preparations; 0/Drug Carriers; 15722-48-2/olsalazine; 599-79-1/Sulfasalazine; 89-57-6/Mesalamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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