| Disposition of infusions of atracurium and its metabolite, laudanosine, in patients in renal and respiratory failure in an ITU. | |
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MedLine Citation:
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PMID: 3207525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of plasma atracurium and laudanosine concentrations was undertaken in 14 critically ill patients who received a bolus dose of atracurium 0.6 mg kg-1 followed by an infusion of 0.6 mg kg-1 h-1 for a period of 11-47 h. Seven of the patients had normal renal function and seven were in acute renal failure. In both groups plasma concentrations of atracurium reached a plateau of approximately 1300 ng ml-1 within 30 min of the bolus dose. The drug disappeared from the plasma within 120 min after discontinuation of the infusion. There was no difference between the two groups with respect to the pharmacokinetic parameters derived for atracurium. In the patients with normal renal function, plasma laudanosine concentration reached a plateau of approximately 1200 ng ml-1 within 10 h. In patients with renal failure there was a greater variation in the plasma laudanosine concentration: the highest value recorded was 4300 ng ml-1. Patients with renal failure had a significantly longer mean elimination half-life for laudanosine (1418 min v. 375 min; P less than 0.05) and Vd (4.52 litre kg-1 v. 2.40 litre kg-1; P less than 0.01) than the patients with normal renal function. |
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Authors:
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C J Parker; J E Jones; J M Hunter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 61 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1989-02-17 Completed Date: 1989-02-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 531-40 Citation Subset: IM |
Affiliation:
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University Department of Anaesthesia, Royal Liverpool Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atracurium / administration & dosage, blood, pharmacokinetics* Critical Care* Female Humans Isoquinolines / blood, metabolism* Kidney Failure, Acute / metabolism* Male Middle Aged Respiratory Insufficiency / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 2688-77-9/laudanosine; 64228-79-1/Atracurium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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