Document Detail


Disposition and excretion of chlorendic acid in Fischer 344 rats.
MedLine Citation:
PMID:  7120517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The absorption, distribution, and excretion of a highly chlorinated dicarboxylic acid, chlorendic acid, was studied in the male Fischer 344 rat. [14C]Chlorendic acid was absorbed after an oral dose of 7.7 mumol per kilogram of body weight. The distribution in various tissues was similar whether the treatment was by the oral or the intravenous route. The major site of [14C]chlorendic acid deposition was the liver, with smaller amounts found in the blood, muscle, skin, and kidneys. Chlorendic acid-derived radioactivity was excreted primarily through the bile and into the feces. The urine contained less than 6% of the total dose. Within 1 d, more than 75% of the total dose was excreted in the feces, primarily as metabolites. Radioactivity in the liver was also primarily metabolites of chlorendic acid. Thus, chlorendic acid was absorbed, metabolized, and excreted primarily in the feces as metabolites. The rapid metabolism and biliary excretion of chlorendic acid contrast with observations for the closely related lipophilic compounds aldrin and dieldrin.
Authors:
G M Decad; M T Fields
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  9     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  911-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Injections, Intravenous
Male
Norbornanes / metabolism*
Rats
Rats, Inbred F344
Tissue Distribution
Chemical
Reg. No./Substance:
0/Norbornanes; 115-28-6/chlorendic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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