| Disposition of cocaine in pregnant sheep. II. Physiological responses. | |
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MedLine Citation:
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PMID: 1914787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied maternal and fetal blood pressure, heart rate, arterial blood gases and fetal behavioral state alterations in response to maternally administered cocaine hydrochloride in 11 pregnant sheep. Cocaine administration to the ewe caused a dose-dependent increase in maternal blood pressure and heart rate and in fetal blood pressure, and a decrease in fetal arterial oxygen tension. In the ewe, blood pressure changes corresponded linearly to dose administered (r = 0.88, p less than 0.001). Blood pressure changes were correlated to peak plasma cocaine concentration in the ewe (r = 0.52, p less than 0.01) and in the fetus (r = 0.43, p = 0.05). In addition, in 7 of 8 fetuses which had entered rapid eye movement (REM) sleep within 5 min of maternal cocaine administration, REM sleep was abruptly terminated either by the cocaine, fetal hypoxia or some other nonspecific event caused by the maternal cocaine administration. Maternal cocaine administration causes maternal and fetal hemodynamic alterations that have potential adverse effects in pregnancy. |
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Authors:
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D J Burchfield; R M Abrams; R Miller; C L DeVane |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental pharmacology and therapeutics Volume: 16 ISSN: 0379-8305 ISO Abbreviation: Dev Pharmacol Ther Publication Date: 1991 |
Date Detail:
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Created Date: 1991-11-01 Completed Date: 1991-11-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8003947 Medline TA: Dev Pharmacol Ther Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 130-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Florida College of Medicine, Gainesville. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cocaine / pharmacology* Female Fetus / drug effects Heart Rate / drug effects Heart Rate, Fetal / drug effects Oxygen / blood Partial Pressure Pregnancy Pregnancy, Animal / drug effects* Sheep |
| Grant Support | |
ID/Acronym/Agency:
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DA 05170/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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