Document Detail


Disposition of cocaine in pregnant sheep. II. Physiological responses.
MedLine Citation:
PMID:  1914787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied maternal and fetal blood pressure, heart rate, arterial blood gases and fetal behavioral state alterations in response to maternally administered cocaine hydrochloride in 11 pregnant sheep. Cocaine administration to the ewe caused a dose-dependent increase in maternal blood pressure and heart rate and in fetal blood pressure, and a decrease in fetal arterial oxygen tension. In the ewe, blood pressure changes corresponded linearly to dose administered (r = 0.88, p less than 0.001). Blood pressure changes were correlated to peak plasma cocaine concentration in the ewe (r = 0.52, p less than 0.01) and in the fetus (r = 0.43, p = 0.05). In addition, in 7 of 8 fetuses which had entered rapid eye movement (REM) sleep within 5 min of maternal cocaine administration, REM sleep was abruptly terminated either by the cocaine, fetal hypoxia or some other nonspecific event caused by the maternal cocaine administration. Maternal cocaine administration causes maternal and fetal hemodynamic alterations that have potential adverse effects in pregnancy.
Authors:
D J Burchfield; R M Abrams; R Miller; C L DeVane
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  16     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-01     Completed Date:  1991-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  130-8     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Florida College of Medicine, Gainesville.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cocaine / pharmacology*
Female
Fetus / drug effects
Heart Rate / drug effects
Heart Rate, Fetal / drug effects
Oxygen / blood
Partial Pressure
Pregnancy
Pregnancy, Animal / drug effects*
Sheep
Grant Support
ID/Acronym/Agency:
DA 05170/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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