| Disposition of ampicillin in honeybees and hives. | |
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MedLine Citation:
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PMID: 9342699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Disposition profile of ampicillin (ABPC) among honeybees, larvae, honey and royal jelly in a hive after oral dosing to adult bees was studied. Four honeybee colonies were administered the single dose of ABPC at the rate of 30 mg/hive by addition to sugar syrup or pollen substitute (paste) for 1 day intake. The colonies received ABPC in syrup showed high drug residue levels in honey and it lasted over 14 days beyond the detection limit of residual analysis. In the hives given ABPC in paste, relatively low honey residues were found, however, the distributions of the drug in young larvae and jelly which was the food of the larvae were very low. ABPC was considered to be a promising drug for the control of American foulbrood, an important bacterial disease of honeybee larvae, because of its high antibacterial activity to the pathogen, Paenibacillus larvae, and instability of residue in honey as human food. The low distribution in young larvae, the target of the disease, threw a doubt on the efficacy of ABPC for American foulbrood control. |
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Authors:
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C Nakajima; A Okayama; T Sakogawa; A Nakamura; T Hayama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 59 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1998-01-12 Completed Date: 1998-01-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: JAPAN |
Other Details:
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Languages: eng Pagination: 765-7 Citation Subset: IM |
Affiliation:
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Research Institute for Animal Science in Biochemistry and Toxicology, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Ampicillin / administration & dosage, analysis, pharmacokinetics* Animals Bees / metabolism*, microbiology Dose-Response Relationship, Drug Fatty Acids / chemistry Honey / analysis, microbiology Larva / metabolism, microbiology Penicillins / administration & dosage, analysis, pharmacokinetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Penicillins; 69-53-4/Ampicillin; 8031-67-2/royal jelly |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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