Document Detail


Disposition of ampicillin in honeybees and hives.
MedLine Citation:
PMID:  9342699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Disposition profile of ampicillin (ABPC) among honeybees, larvae, honey and royal jelly in a hive after oral dosing to adult bees was studied. Four honeybee colonies were administered the single dose of ABPC at the rate of 30 mg/hive by addition to sugar syrup or pollen substitute (paste) for 1 day intake. The colonies received ABPC in syrup showed high drug residue levels in honey and it lasted over 14 days beyond the detection limit of residual analysis. In the hives given ABPC in paste, relatively low honey residues were found, however, the distributions of the drug in young larvae and jelly which was the food of the larvae were very low. ABPC was considered to be a promising drug for the control of American foulbrood, an important bacterial disease of honeybee larvae, because of its high antibacterial activity to the pathogen, Paenibacillus larvae, and instability of residue in honey as human food. The low distribution in young larvae, the target of the disease, threw a doubt on the efficacy of ABPC for American foulbrood control.
Authors:
C Nakajima; A Okayama; T Sakogawa; A Nakamura; T Hayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  59     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-12     Completed Date:  1998-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  765-7     Citation Subset:  IM    
Affiliation:
Research Institute for Animal Science in Biochemistry and Toxicology, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Ampicillin / administration & dosage,  analysis,  pharmacokinetics*
Animals
Bees / metabolism*,  microbiology
Dose-Response Relationship, Drug
Fatty Acids / chemistry
Honey / analysis,  microbiology
Larva / metabolism,  microbiology
Penicillins / administration & dosage,  analysis,  pharmacokinetics*
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Penicillins; 69-53-4/Ampicillin; 8031-67-2/royal jelly

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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