Document Detail


Disposition of acetaminophen in milk, saliva, and plasma of lactating women.
MedLine Citation:
PMID:  7202185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acetaminophen (APAP) is a widely used analgesic and antipyretic, but its disposition in human milk has not yet been reported. Twelve nursing mothers (nursing two to 22 months) were given a single 650-mg peroral dose of APAP. Simultaneous saliva and milk samples were collected at zero, 1/4, 1/2, 3/4, 1, 2, 3, 5, 8, 12, and 24 hours after maternal dosing. In two mothers, plasma samples were also obtained at several points during the first six hours. Single voided urine samples were collected from the infants three to five hours after maternal dosing (two hours after nursing at peak maternal milk levels). All samples were assayed for APAP by high pressure liquid chromatography (HPCL) using a mobile phase of 0.05 M Na acetate pH 4.0-acetonitrile (93:10) with n-butyryl-p-aminophenol as the internal standard. APAP appeared in saliva and milk in the 1/4-hour samples; peak level (10-15 micrograms/ml) were achieved by one to two hours. Saliva/milk ratios during the elimination phase ranged from 0.7 to 1.1, with most values between 0.8 and 0.9. In two patients studied, saliva/plasma ratios were 0.9 to 1.0. Elimination phase t 1/2 (calculated from beta) ranged from 1.35 to 3.50 (x = 2.28 +/- SD 0.69) hours for milk, and from 1.72 to 3.30 (x = 2.48 +/- 0.56) hours for saliva. There was close agreement between saliva t 1/2 and milk t 1/2 for each patient. Assuming each infant ingested 90 ml milk at 3, 6, and 9 hours after maternal ingestion of APAP, the amount of APAP available for ingestion ranged from 0.28 to 1.51 mg (x = 0.88 +/- 0.31) or from 0.04% to 0.23% (x = 0.14 +/- 0.04) of maternal dose. Neither APAP nor metabolite was detected in nursing infants' urine. Maternal APAP ingestion in usual analgesic doses does not appear to present a risk to the nursing infant.
Authors:
C M Berlin; S J Yaffe; M Ragni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pharmacology (New York, N.Y.)     Volume:  1     ISSN:  0270-322X     ISO Abbreviation:  Pediatr Pharmacol (New York)     Publication Date:  1980  
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8400778     Medline TA:  Pediatr Pharmacol (New York)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood,  metabolism*
Adult
Aging
Chromatography, High Pressure Liquid / methods
Female
Half-Life
Humans
Lactation
Milk, Human / metabolism*
Pregnancy
Saliva / metabolism*
Time Factors
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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