Document Detail


Disposition of 5-methyltetrahydrohomofolate in mice, dogs, and monkeys.
MedLine Citation:
PMID:  109197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacologic disposition of [methyl-14C]5-methyltetrahydrohomofolate (MTHHF) has been studied in mice, dogs, and monkeys after parenteral administration of doses of 150 and 1500 mg/m2. Thin-layer chromatography and high-pressure liquid chromatography were used to separate the parent compound from its products. Following ip injection of MTHHF into mice, serum levels rose to a maximum within 1 hour and decreased with a half-life of about 50 minutes. The liver, kidneys, and small intestine of mice contained concentrations of MTHHF greater than that of serum. For dogs and monkeys given an iv injection of MTHHF, serum levels declined in three phases. The third phase was probably associated primarily with loss of the drug from the liver and intestine, where relatively large amounts were retained. Within 24 hours after administration of MTHHF, the percent recovery in the urine was 69% for mice, 78% for dogs, and 50%--60% for monkeys. For mice and dogs an additional 2%--17% was recovered in the feces within 24 hours. Over a period of 3 days after injection with the high dose in a monkey, 24% of the dose was present in the feces. For all three species, 90%--99% of the radioactivity in the serum, urine, and feces was unchanged MTHHF, indicating that very little metabolism or decomposition had occurred. Less than 0.3% of the dose was recovered from monkeys as radioactive CO2.
Authors:
S M El Dareer; K F Tillery; D L Hill
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer treatment reports     Volume:  63     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Proteins / metabolism
Dogs
Female
Folic Acid / administration & dosage,  analogs & derivatives*,  metabolism
Haplorhini
Male
Metabolic Clearance Rate
Mice
Species Specificity
Tissue Distribution
Chemical
Reg. No./Substance:
0/Blood Proteins; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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