Document Detail

Disposal of cell debris from surplus lactotrophs of pituitary gland.
MedLine Citation:
PMID:  8817244     Owner:  NLM     Status:  MEDLINE    
In rats submitted to physiological and experimental stimulation of lactotrophic secretion, as in pregnancy and lactation as well as after estrogen treatment, there is a remarkable proliferation of lactotrophs in the pituitary gland. After interruption of the stimuli, this situation is reversed to basal conditions via a massive programmed cell death of the surplus lactotrophs. The regressive changes occurring in lactotrophs are autolytic in nature, until the advanced stages of degeneration when the cell debris generated by this process are engulfed by phagocytes exhibiting the morphological characteristics of stellate cells. These cells can be seen within the anterior pituitary parenchyma adherent to the wall of capillaries and in the lumen of blood vessels. The number of stellate cells with engulfed lactotroph cell remnants is relatively small in comparison to the massive cell death, an observation that suggests a rapid clearance of cell debris and phagocytic cells from the pituitary parenchyma into the blood stream. The migration of stellate cells from the adenohypophysis involves the degradation of the basement membrane and rearrangement of the capillary wall components. The final disposal of cell debris of regressing lactotrophs within the anterior pituitary therefore appears to be effected by coordination of a pituitary and systemic mononuclear phagocytic system.
A Aoki; E O de Gaisán; H A Pasolli; A I Torres
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association     Volume:  104     ISSN:  0947-7349     ISO Abbreviation:  Exp. Clin. Endocrinol. Diabetes     Publication Date:  1996  
Date Detail:
Created Date:  1996-11-22     Completed Date:  1996-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505926     Medline TA:  Exp Clin Endocrinol Diabetes     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  256-62     Citation Subset:  IM    
Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
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MeSH Terms
Estradiol / pharmacology*
Microscopy, Electron
Phagocytes / cytology,  ultrastructure
Pituitary Gland, Anterior / drug effects,  physiology*,  ultrastructure*
Rats, Wistar
Reg. No./Substance:

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