| Disposable bioprocessing: the future has arrived. | |
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MedLine Citation:
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PMID: 19090536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing cost pressures are driving the rapid adoption of disposables in bioprocessing. While well ensconced in lab-scale operations, the lower operating/ validation costs at larger scale and relative ease of use are leading to these systems entering all stages and operations of a typical biopharmaceutical manufacturing process. Here, we focus on progress made in the incorporation of disposable equipment with sensor technology in bioprocessing throughout the development cycle. We note that sensor patch technology is mostly being adapted to disposable cell culture devices, but future adaptation to downstream steps is conceivable. Lastly, regulatory requirements are also briefly assessed in the context of disposables and the Process Analytical Technologies (PAT) and Quality by Design (QbD) initiatives. |
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Authors:
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Govind Rao; Antonio Moreira; Kurt Brorson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 102 ISSN: 1097-0290 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2008-12-29 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 348-56 Citation Subset: IM |
Affiliation:
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Center for Advanced Sensor Technology, Department of Chemical and Biochemical Engineering, TRC, UMBC, Baltimore, Maryland 21250, USA. grao@umbc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques
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methods* Biotechnology / instrumentation*, trends* Cell Culture Techniques / instrumentation*, trends Disposable Equipment / standards, trends* Equipment Design |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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