Document Detail


Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI.
MedLine Citation:
PMID:  17513129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regional investigations of newborn MRI are important to understand the appearance and consequences of early brain injury. Previously, regionalization in neonates has been achieved with a Talairach parcellation, using internal landmarks of the brain. Non-synostotic dolichocephaly defines a bi-temporal narrowing of the preterm infant's head caused by pressure on the immature skull. The impact of dolichocephaly on brain shape and regional brain shift, which may compromise the validity of the parcellation scheme, has not yet been investigated. Twenty-four preterm and 20 fullterm infants were scanned at term equivalent. Skull shapes were investigated by cephalometric measurements and population registration. Brain tissue volumes were calculated to rule out brain injury underlying skull shape differences. The position of Talairach landmarks was evaluated. Cortical structures were segmented to determine a positional shift between both groups. The preterm group displayed dolichocephalic head shapes and had similar brain volumes compared to the mesocephalic fullterm group. In preterm infants, Talairach landmarks were consistently positioned relative to each other and to the skull base, but were displaced with regard to the calvarium. The frontal and superior region was enlarged; central and temporal gyri and sulci were shifted comparing preterm and fullterm infants. We found that, in healthy preterm infants, dolichocephaly led to a shift of cortical structures, but did not influence deep brain structures. We concluded that the validity of a Talairach parcellation scheme is compromised and may lead to a miscalculation of regional brain volumes and inconsistent parcel contents when comparing infant populations with divergent head shapes.
Authors:
Andrea U J Mewes; Lilla Zöllei; Petra S Hüppi; Heidelise Als; Gloria B McAnulty; Terrie E Inder; William M Wells; Simon K Warfield
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-04-18
Journal Detail:
Title:  NeuroImage     Volume:  36     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-10-18     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1074-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / pathology*
Cephalometry / methods*
Cerebral Cortex / pathology
Craniosynostoses / diagnosis*
Diagnosis, Differential
Female
Humans
Image Processing, Computer-Assisted*
Imaging, Three-Dimensional*
Infant, Newborn
Infant, Premature, Diseases / diagnosis*
Magnetic Resonance Imaging*
Male
Mesencephalon / pathology
Reference Values
Sensitivity and Specificity
Skull / abnormalities*
Skull Base / pathology
Grant Support
ID/Acronym/Agency:
P30 HD018655-169008/HD/NICHD NIH HHS; P30 HD18655/HD/NICHD NIH HHS; P41 RR013218/RR/NCRR NIH HHS; P41 RR013218-010005/RR/NCRR NIH HHS; P41RR13218/RR/NCRR NIH HHS; R01 EB013248/EB/NIBIB NIH HHS; R01 HD046855/HD/NICHD NIH HHS; R01 HD046855/HD/NICHD NIH HHS; R01 HD046855-01/HD/NICHD NIH HHS; R01 HD047730/HD/NICHD NIH HHS; R01 HD047730/HD/NICHD NIH HHS; R01 HD047730-01A2/HD/NICHD NIH HHS; R01 RR021885/RR/NCRR NIH HHS; R01 RR021885/RR/NCRR NIH HHS; R01 RR021885-01A1/RR/NCRR NIH HHS; R03 CA126466/CA/NCI NIH HHS; R03 CA126466/CA/NCI NIH HHS; R03 CA126466-01A1/CA/NCI NIH HHS; R21 MH067054/MH/NIMH NIH HHS; R21 MH067054/MH/NIMH NIH HHS; R21 MH067054-01A1/MH/NIMH NIH HHS; U41 RR019703/RR/NCRR NIH HHS; U41 RR019703-01A2/RR/NCRR NIH HHS; U41RR019703-01A2/RR/NCRR NIH HHS
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