| Displacement of brain regions in preterm infants with non-synostotic dolichocephaly investigated by MRI. | |
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MedLine Citation:
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PMID: 17513129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional investigations of newborn MRI are important to understand the appearance and consequences of early brain injury. Previously, regionalization in neonates has been achieved with a Talairach parcellation, using internal landmarks of the brain. Non-synostotic dolichocephaly defines a bi-temporal narrowing of the preterm infant's head caused by pressure on the immature skull. The impact of dolichocephaly on brain shape and regional brain shift, which may compromise the validity of the parcellation scheme, has not yet been investigated. Twenty-four preterm and 20 fullterm infants were scanned at term equivalent. Skull shapes were investigated by cephalometric measurements and population registration. Brain tissue volumes were calculated to rule out brain injury underlying skull shape differences. The position of Talairach landmarks was evaluated. Cortical structures were segmented to determine a positional shift between both groups. The preterm group displayed dolichocephalic head shapes and had similar brain volumes compared to the mesocephalic fullterm group. In preterm infants, Talairach landmarks were consistently positioned relative to each other and to the skull base, but were displaced with regard to the calvarium. The frontal and superior region was enlarged; central and temporal gyri and sulci were shifted comparing preterm and fullterm infants. We found that, in healthy preterm infants, dolichocephaly led to a shift of cortical structures, but did not influence deep brain structures. We concluded that the validity of a Talairach parcellation scheme is compromised and may lead to a miscalculation of regional brain volumes and inconsistent parcel contents when comparing infant populations with divergent head shapes. |
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Authors:
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Andrea U J Mewes; Lilla Zöllei; Petra S Hüppi; Heidelise Als; Gloria B McAnulty; Terrie E Inder; William M Wells; Simon K Warfield |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-04-18 |
Journal Detail:
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Title: NeuroImage Volume: 36 ISSN: 1053-8119 ISO Abbreviation: Neuroimage Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-06 Completed Date: 2007-10-18 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1074-85 Citation Subset: IM |
Affiliation:
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Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. mewes@bwh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Cephalometry / methods* Cerebral Cortex / pathology Craniosynostoses / diagnosis* Diagnosis, Differential Female Humans Image Processing, Computer-Assisted* Imaging, Three-Dimensional* Infant, Newborn Infant, Premature, Diseases / diagnosis* Magnetic Resonance Imaging* Male Mesencephalon / pathology Reference Values Sensitivity and Specificity Skull / abnormalities* Skull Base / pathology |
| Grant Support | |
ID/Acronym/Agency:
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P30 HD018655-169008/HD/NICHD NIH HHS; P30 HD18655/HD/NICHD NIH HHS; P41 RR013218/RR/NCRR NIH HHS; P41 RR013218-010005/RR/NCRR NIH HHS; P41RR13218/RR/NCRR NIH HHS; R01 EB013248/EB/NIBIB NIH HHS; R01 HD046855/HD/NICHD NIH HHS; R01 HD046855-01/HD/NICHD NIH HHS; R01 HD047730/HD/NICHD NIH HHS; R01 HD047730-01A2/HD/NICHD NIH HHS; R01 RR021885/RR/NCRR NIH HHS; R01 RR021885-01A1/RR/NCRR NIH HHS; R03 CA126466/CA/NCI NIH HHS; R03 CA126466-01A1/CA/NCI NIH HHS; R21 MH067054/MH/NIMH NIH HHS; R21 MH067054-01A1/MH/NIMH NIH HHS; U41 RR019703/RR/NCRR NIH HHS; U41 RR019703-01A2/RR/NCRR NIH HHS; U41RR019703-01A2/RR/NCRR NIH HHS |
| Comments/Corrections | |
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