| Displacement of bilirubin from albumin by ibuprofen in vitro. | |
| | |
MedLine Citation:
|
PMID: 20216106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ibuprofen binds to plasma albumin and could interfere with the binding of bilirubin in jaundiced newborn infants. Most clinical studies have not shown increased concentrations of unbound bilirubin (UB) in plasma from infants treated with ibuprofen for a patent ductus arteriosus. However, studies in vitro have not been equally conclusive. Plasma were obtained from routine samples from jaundiced newborn infants and pooled. Total and UB were measured with the peroxidase method after addition of ibuprofen or sulfisoxazole as a known bilirubin displacer. Final ibuprofen concentrations varied from 0.43 to 2.6 mM. Bilirubin concentrations were varied from 176 to 708 microM by adding bilirubin to plasma samples. Ibuprofen caused a linear increase in UB up to +54% at a concentration of 1.8 mM, compared with an increase of 87% by sulfisoxazole (1.32 mM). A double reciprocal plot of molar concentrations of bound versus UB at bilirubin concentrations ranging from 176 to 708 microM showed a competitive displacement of bilirubin by ibuprofen. The data indicate that ibuprofen is a competitive displacer of bilirubin in vitro. Ibuprofen should be used with caution in premature infants with a significant hyperbilirubinemia. |
| | |
Authors:
|
Hanne T Soligard; Odd G Nilsen; Dag Bratlid |
Related Documents
:
|
6673486 - Phototherapy-associated diarrhea. the role of bile salts. 2651596 - Phototherapy--1988. a green light for a new approach? 399916 - Phototherapy for neonatal hyperbilirubinemia--a potential environmental health hazard t... 12244276 - The jaundiced newborn. understanding and managing transitional hyperbilirubinemia. 9835396 - Innate and learned perceptual abilities in the newborn infant. 8517896 - Intrauterine tachycardia and periventricular leukomalacia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatric research Volume: 67 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-18 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 614-8 Citation Subset: IM |
Affiliation:
|
Department of Cancer Research and Molecular Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, and Department of Pediatrics and Adolescent Medicine, St. Olavs University Hospital, Trondheim, N-7006, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bilirubin
/
blood* Binding Sites Binding, Competitive Cyclooxygenase Inhibitors / adverse effects, blood* Humans Hyperbilirubinemia, Neonatal / blood*, complications Ibuprofen / adverse effects, blood* Infant, Newborn Jaundice, Neonatal / blood*, etiology Serum Albumin / metabolism* Sulfisoxazole / blood Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Cyclooxygenase Inhibitors; 0/Serum Albumin; 127-69-5/Sulfisoxazole; 15687-27-1/Ibuprofen; 635-65-4/Bilirubin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adiposity Is Not Altered In Preterm Infants Fed a Nutrient-Enriched Formula After Hospital Discharge...
Next Document: Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic mu...