Document Detail


Displacement of bilirubin from albumin by ibuprofen in vitro.
MedLine Citation:
PMID:  20216106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ibuprofen binds to plasma albumin and could interfere with the binding of bilirubin in jaundiced newborn infants. Most clinical studies have not shown increased concentrations of unbound bilirubin (UB) in plasma from infants treated with ibuprofen for a patent ductus arteriosus. However, studies in vitro have not been equally conclusive. Plasma were obtained from routine samples from jaundiced newborn infants and pooled. Total and UB were measured with the peroxidase method after addition of ibuprofen or sulfisoxazole as a known bilirubin displacer. Final ibuprofen concentrations varied from 0.43 to 2.6 mM. Bilirubin concentrations were varied from 176 to 708 microM by adding bilirubin to plasma samples. Ibuprofen caused a linear increase in UB up to +54% at a concentration of 1.8 mM, compared with an increase of 87% by sulfisoxazole (1.32 mM). A double reciprocal plot of molar concentrations of bound versus UB at bilirubin concentrations ranging from 176 to 708 microM showed a competitive displacement of bilirubin by ibuprofen. The data indicate that ibuprofen is a competitive displacer of bilirubin in vitro. Ibuprofen should be used with caution in premature infants with a significant hyperbilirubinemia.
Authors:
Hanne T Soligard; Odd G Nilsen; Dag Bratlid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  67     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-8     Citation Subset:  IM    
Affiliation:
Department of Cancer Research and Molecular Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, and Department of Pediatrics and Adolescent Medicine, St. Olavs University Hospital, Trondheim, N-7006, Norway.
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood*
Binding Sites
Binding, Competitive
Cyclooxygenase Inhibitors / adverse effects,  blood*
Humans
Hyperbilirubinemia, Neonatal / blood*,  complications
Ibuprofen / adverse effects,  blood*
Infant, Newborn
Jaundice, Neonatal / blood*,  etiology
Serum Albumin / metabolism*
Sulfisoxazole / blood
Time Factors
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Serum Albumin; 127-69-5/Sulfisoxazole; 15687-27-1/Ibuprofen; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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