| Dispersions of repolarization and ventricular arrhythmogenesis: lessons from animal models. | |
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MedLine Citation:
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PMID: 19027779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths per year in the US alone. Within the past forty years we have taken considerable leaps forward in our understanding of the causes and mechanisms underlying cardiac arrhythmias, particularly in the setting of inherited and acquired dysfunctions in ionic currents which constitute human long QT syndrome (LQTS). Impaired repolarization seen in LQTS commonly gives rise to an altered dispersion of repolarization, which is considered to provide the functional substrate necessary for the perpetuation of lethal arrhythmias. This review examines the bases for arrhythmias arising from repolarization heterogeneities and explores the applicability of the genetically amenable mouse for the study of arrhythmias arising from such mechanisms. |
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Authors:
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Matthew J Killeen; Ian N Sabir; Andrew A Grace; Christopher L-H Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-11-07 |
Journal Detail:
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Title: Progress in biophysics and molecular biology Volume: 98 ISSN: 0079-6107 ISO Abbreviation: Prog. Biophys. Mol. Biol. Publication Date: 2008 Oct-Nov |
Date Detail:
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Created Date: 2009-03-16 Completed Date: 2009-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401233 Medline TA: Prog Biophys Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 219-29 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Centre, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA. matthew.killeen@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Arrhythmias, Cardiac / etiology, physiopathology* Death, Sudden, Cardiac / etiology Disease Models, Animal Dogs Electrophysiological Phenomena Heart Ventricles / physiopathology Humans Long QT Syndrome / congenital, etiology, physiopathology Mice |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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