| Dispersed donor salivary gland cells are widely distributed in the recipient gland when infused up the ductal tree. | |
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MedLine Citation:
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PMID: 19572222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The salivary glands often are severely and permanently damaged by therapeutic irradiation for cancer of the head and neck. The markedly reduced quantity and quality of saliva results in greatly increased susceptibility to dental caries and infection of the oral mucosa and alveolar bone. Recently, subcapsular injection of cultured mouse salivary gland cells has achieved a significant degree of regeneration in a previously irradiated mouse salivary gland; however, the recovery was limited to one lobule. We describe here a method for delivering donor rat salivary gland cells via the main duct that distributes several thousand cells throughout the recipient rat's salivary gland. The donated cells exhibited the cytodifferentiation of the structures in which they lodged, i.e., acini, granular convoluted tubules, and the several types of ducts. This method may facilitate the simultaneous functional recovery of almost all of the lobules of irradiated rat salivary glands. |
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Authors:
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R S Redman; W D Ball; E Mezey; S Key |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biotechnic & histochemistry : official publication of the Biological Stain Commission Volume: 84 ISSN: 1473-7760 ISO Abbreviation: Biotech Histochem Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-06-25 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 9107378 Medline TA: Biotech Histochem Country: England |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM |
Affiliation:
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Oral Pathology Research Laboratory (151-I), Department of Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA. oralpath@erols.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Culture Techniques Cell Transplantation / methods* Cells, Cultured Female Male Mouth Mucosa / physiopathology Rats Rats, Sprague-Dawley Recovery of Function* Regeneration* Saliva Salivary Gland Diseases / physiopathology* Salivary Glands / cytology*, radiation effects Specific Pathogen-Free Organisms Tissue Donors |
| Grant Support | |
ID/Acronym/Agency:
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DE 14995/DE/NIDCR NIH HHS; R21 DE014995-02/DE/NIDCR NIH HHS |
| Comments/Corrections | |
Erratum In:
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Biotech Histochem. 2010 Feb;85(1):87 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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