| Disparity in circulating adiponectin multimers between term and preterm infants. | |
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MedLine Citation:
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PMID: 19591556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To study circulating levels and distribution of adiponectin multimers [low molecular weight (LMW)-, medium molecular weight (MMW)- and high molecular weight (HMW)-adiponectin] in preterm and full-term infants. METHODS: Total serum adiponectin and its multimers were measured in 40 healthy infants at the age of one month and associations with anthropometric parameters [body weight and length, body mass index (BMI)], weight gain and metabolic indices (glucose, insulin) were examined. Twenty of the infants were born preterm (gestational age 33.2+/-1.6 weeks). RESULTS: LMW-adiponectin level and its fractional ratio to total adiponectin were significantly higher in full-term than in preterm infants (P<0.001 and P<0.01, respectively), whereas, MMW-adiponectin level and its ratio were significantly lower (P=0.03 and P=0.01, respectively). HMW-adiponectin did not differ significantly between full-term and preterm infants and accounted for almost 60% of total adiponectin levels in both groups. HMW-adiponectin, but not MMW adiponectin or LMW adiponectin, correlated significantly with anthropometric measurements, similarly to total adiponectin; in addition, HMW adiponectin correlated significantly with weight gain. CONCLUSIONS: HMW adiponectin is the most prevalent form in infants. Circulating levels and distribution of MMW- and LMW-adiponectin differ between full-term and preterm infants, but the role of these adiponectin multimers needs to be studied further. |
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Authors:
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Tania Siahanidou; Alexandra Margeli; Maria Garatzioti; Maria Davradou; Filia Apostolakou; Ioannis Papassotiriou; Helen Mandyla |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of perinatal medicine Volume: 37 ISSN: 1619-3997 ISO Abbreviation: J Perinat Med Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-02-05 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: Germany |
Other Details:
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Languages: eng Pagination: 683-8 Citation Subset: IM |
Affiliation:
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Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Athens, Greece. neonat5@paidon-agiasofia.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood,
chemistry Birth Weight Body Mass Index Case-Control Studies Female Gestational Age Humans Infant Infant, Newborn Infant, Premature / blood* Male Molecular Weight Pregnancy Protein Structure, Quaternary Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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