Document Detail

Disparity in circulating adiponectin multimers between term and preterm infants.
MedLine Citation:
PMID:  19591556     Owner:  NLM     Status:  MEDLINE    
AIMS: To study circulating levels and distribution of adiponectin multimers [low molecular weight (LMW)-, medium molecular weight (MMW)- and high molecular weight (HMW)-adiponectin] in preterm and full-term infants.
METHODS: Total serum adiponectin and its multimers were measured in 40 healthy infants at the age of one month and associations with anthropometric parameters [body weight and length, body mass index (BMI)], weight gain and metabolic indices (glucose, insulin) were examined. Twenty of the infants were born preterm (gestational age 33.2+/-1.6 weeks).
RESULTS: LMW-adiponectin level and its fractional ratio to total adiponectin were significantly higher in full-term than in preterm infants (P<0.001 and P<0.01, respectively), whereas, MMW-adiponectin level and its ratio were significantly lower (P=0.03 and P=0.01, respectively). HMW-adiponectin did not differ significantly between full-term and preterm infants and accounted for almost 60% of total adiponectin levels in both groups. HMW-adiponectin, but not MMW adiponectin or LMW adiponectin, correlated significantly with anthropometric measurements, similarly to total adiponectin; in addition, HMW adiponectin correlated significantly with weight gain.
CONCLUSIONS: HMW adiponectin is the most prevalent form in infants. Circulating levels and distribution of MMW- and LMW-adiponectin differ between full-term and preterm infants, but the role of these adiponectin multimers needs to be studied further.
Tania Siahanidou; Alexandra Margeli; Maria Garatzioti; Maria Davradou; Filia Apostolakou; Ioannis Papassotiriou; Helen Mandyla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  37     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-02-05     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  683-8     Citation Subset:  IM    
Neonatal Unit, First Department of Pediatrics, Athens University Medical School, Athens, Greece.
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MeSH Terms
Adiponectin / blood,  chemistry
Birth Weight
Body Mass Index
Case-Control Studies
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Molecular Weight
Protein Structure, Quaternary
Weight Gain
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin

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