Document Detail


Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions.
MedLine Citation:
PMID:  17966427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
YopP in Y. enterocolitica and YopJ in Y. pseudotuberculosis, have been shown to exert a variety of adverse effects on cell signaling leading to suppression of cytokine expression and induction of programmed cell death. A comparative in vitro study with Y. pestis and Y. enterocolitica O:8 virulent strains shows some critical disparity in YopJ/YopP-related effects on immune cells. Involvement of yopJ in virulence was evaluated in mouse model of bubonic plague.
Authors:
Ayelet Zauberman; Baruch Velan; Emanuelle Mamroud; Yehuda Flashner; Avigdor Shafferman; Sara Cohen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  603     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-20     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Bacterial Proteins / genetics,  physiology*
Genes, Bacterial
Host-Pathogen Interactions
Humans
MAP Kinase Signaling System
NF-kappa B / metabolism
Signal Transduction
Species Specificity
Tumor Necrosis Factor-alpha / biosynthesis
Yersinia enterocolitica / genetics,  pathogenicity,  physiology*
Yersinia pestis / genetics,  pathogenicity,  physiology*
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/NF-kappa B; 0/Tumor Necrosis Factor-alpha; 0/YopP protein, Yersinia

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