Document Detail

Disparate hemodynamic and sympathoadrenergic responses to isometric and mental stress in essential hypertension.
MedLine Citation:
PMID:  2662733     Owner:  NLM     Status:  MEDLINE    
The hemodynamic and sympathoadrenergic responses during isometric handgrip and mental arithmetic tests were compared in 18 patients with mild essential hypertension. Mean blood pressure increased significantly after both maneuvers (27% during isometric stress and 10.7% during mental stress), but the increase was significantly higher during isometric stress (p less than 0.001). Both stressors increased the heart rate (p less than 0.001) and cardiac output (p less than 0.001). However, the total peripheral resistance behaved differently, for it increased during isometric stress (p less than 0.05) and remained unchanged during mental stress. Both stressors increased the epinephrine levels (p less than 0.005), but only isometric stress increased the norepinephrine levels (p less than 0.001). It is concluded that both stressors increase cardiac output by way of an increase in heart rate, but isometric stress also increases total peripheral resistance and thus causes a greater increase in arterial pressure. Isometric stress activates both the adrenergic and noradrenergic systems, thereby accounting for the exaggerated response in arterial pressure, whereas mental stress stimulates the adrenergic system only.
E Grossman; S Oren; G E Garavaglia; R Schmieder; F H Messerli
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  64     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-03     Completed Date:  1989-08-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-4     Citation Subset:  AIM; IM    
Department of Internal Medicine, Ochsner Clinic, New Orleans, Louisiana.
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MeSH Terms
Cardiac Output
Dopamine / blood
Epinephrine / blood
Heart Rate
Hypertension / blood,  physiopathology*
Isometric Contraction*
Mental Processes / physiology
Middle Aged
Muscle Contraction*
Norepinephrine / blood
Renin / blood
Stress, Physiological / blood,  physiopathology*
Stress, Psychological / blood,  physiopathology*
Vascular Resistance
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC

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