| Disparate effects of exercise training on glucose tolerance and insulin levels and on ambulatory blood pressure in hypertensive patients. | |
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MedLine Citation:
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PMID: 8258677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the relationship of insulin levels and glucose tolerance to blood pressure in hypertension. DESIGN: An open, prospective trial of exercise training with ambulatory blood pressure monitoring and intravenous glucose tolerance testing before and after a 14-week training programme. PATIENTS: Twenty sedentary, untreated, non-obese, normoglycaemic individuals of both sexes with uncomplicated essential hypertension, of whom 16 completed the study. INTERVENTION: Fourteen weeks of supervised, low-intensity, group exercise of three 1-h sessions per week. MAIN OUTCOME MEASURES: Ambulatory and clinic blood pressure, and glucose and insulin responses to an intravenous glucose tolerance test. RESULTS: Maximal work capacity on a bicycle ergometer increased by 20% (P < 0.001); 24-h ambulatory blood pressure was 143 +/- 12/87 +/- 5 mmHg before and 142 +/- 13/87 +/- 7 mmHg after training. Clinic blood pressure decreased from 166 +/- 14/103 +/- 5 mmHg to 157 +/- 12/99 +/- 6 mmHg (P < 0.03). Two-way analysis of variance indicated significant decreases in both glucose (P < 0.04) and insulin (P < 0.03), fasting and throughout the intravenous glucose tolerance test. CONCLUSIONS: Although mild exercise reduced clinic blood pressure significantly, it did not affect ambulatory blood pressure despite a marked reduction in glucose and insulin levels. This finding argues against a determinant role of insulin in the 24-h maintenance of blood pressure in hypertensive patients under the conditions of the study. |
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Authors:
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M Bursztyn; D Ben-Ishay; M Shochina; J Mekler; I Raz |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 11 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-01-19 Completed Date: 1994-01-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1121-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ambulatory Care Analysis of Variance Blood Glucose / metabolism* Blood Pressure* Blood Pressure Determination / methods Female Glucose Tolerance Test Humans Hypertension / blood, physiopathology* Infusions, Intravenous Insulin / blood* Male Middle Aged Physical Education and Training* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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