| Disparate Consequences of Heat Stress Exposure during Meiotic Maturation: Embryo Development after Chemical Activation versus Fertilization of Bovine Oocytes. | |
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MedLine Citation:
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PMID: 21994359 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Consequences of heat stress exposure during the first 12 h of meiotic maturation differed depending on how and when bovine oocytes were activated. If heat-stressed oocytes underwent in vitro fertilization at ~24 h, blastocyst development was less than for respective controls and similar to that obtained for nonheat-stressed oocytes undergoing in vitro fertilization at 30 h (i.e., slightly aged). In contrast, if heat-stressed oocytes underwent chemical activation with ionomycin/6-dimethylaminopurine at 24 h, blastocyst development was not only higher than respective controls, but also equivalent to development obtained after activation of nonheat-stressed oocytes at 30 h. Developmental differences in chemically-activated versus in vitro fertilization-derived embryos were not related to fertilization failure or gross alterations in cytoskeletal components. Rather, ionomycin-induced calcium release and mitogen-activated protein kinase activity were less in heat-stressed oocytes. While underlying mechanisms are multifactorial, ability to obtain equivalent or higher development after parthenogenetic activation demonstrates that oocytes experiencing heat stress during the first 12 h of meiotic maturation have the necessary components to develop to the blastocyst stage, but fail to do so after fertilization. |
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Authors:
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Louisa A Rispoli; Janelle L Lawrence; Rebecca R Payton; Arnold M Saxton; Gretchen E Schrock; F Neal Schrick; Brooks W Middlebrooks; John R Dunlap; John J Parrish; J Lannett Edwards |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: - ISSN: 1741-7899 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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L Rispoli, Department of Animal Science, The University of Tennessee, Knoxville, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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