Document Detail


Disparate Consequences of Heat Stress Exposure during Meiotic Maturation: Embryo Development after Chemical Activation versus Fertilization of Bovine Oocytes.
MedLine Citation:
PMID:  21994359     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Consequences of heat stress exposure during the first 12 h of meiotic maturation differed depending on how and when bovine oocytes were activated. If heat-stressed oocytes underwent in vitro fertilization at ~24 h, blastocyst development was less than for respective controls and similar to that obtained for nonheat-stressed oocytes undergoing in vitro fertilization at 30 h (i.e., slightly aged). In contrast, if heat-stressed oocytes underwent chemical activation with ionomycin/6-dimethylaminopurine at 24 h, blastocyst development was not only higher than respective controls, but also equivalent to development obtained after activation of nonheat-stressed oocytes at 30 h. Developmental differences in chemically-activated versus in vitro fertilization-derived embryos were not related to fertilization failure or gross alterations in cytoskeletal components. Rather, ionomycin-induced calcium release and mitogen-activated protein kinase activity were less in heat-stressed oocytes. While underlying mechanisms are multifactorial, ability to obtain equivalent or higher development after parthenogenetic activation demonstrates that oocytes experiencing heat stress during the first 12 h of meiotic maturation have the necessary components to develop to the blastocyst stage, but fail to do so after fertilization.  
Authors:
Louisa A Rispoli; Janelle L Lawrence; Rebecca R Payton; Arnold M Saxton; Gretchen E Schrock; F Neal Schrick; Brooks W Middlebrooks; John R Dunlap; John J Parrish; J Lannett Edwards
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-12
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  -     ISSN:  1741-7899     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
L Rispoli, Department of Animal Science, The University of Tennessee, Knoxville, United States.
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