Document Detail

Disorders of cochlear blood flow.
MedLine Citation:
PMID:  14499459     Owner:  NLM     Status:  MEDLINE    
The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery. Cochlear blood flow is a function of cochlear perfusion pressure, which is calculated as the difference between mean arterial blood pressure and inner ear fluid pressure. Many otologic disorders such as noise-induced hearing loss, endolymphatic hydrops and presbycusis are suspected of being related to alterations in cochlear blood flow. However, the human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. In patients with sensorineural hearing loss, magnetic resonance imaging, laser-Doppler flowmetry and ultrasonography have been used to investigate the status of cochlear blood flow. There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases.
Tsutomu Nakashima; Shinji Naganawa; Michihiko Sone; Mitsuo Tominaga; Hideo Hayashi; Hiroshi Yamamoto; Xiuli Liu; Alfred L Nuttall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Brain research. Brain research reviews     Volume:  43     ISSN:  -     ISO Abbreviation:  Brain Res. Brain Res. Rev.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-22     Completed Date:  2004-01-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8908638     Medline TA:  Brain Res Brain Res Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-28     Citation Subset:  IM    
Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan.
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MeSH Terms
Basilar Artery / anatomy & histology,  physiopathology
Cochlea / blood supply*,  physiopathology
Disease Models, Animal
Guinea Pigs
Hearing Loss, Sensorineural / etiology*,  physiopathology*
Homeostasis / physiology
Nitric Oxide / metabolism
Regional Blood Flow / physiology*
Vascular Diseases / complications*,  physiopathology*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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