Document Detail

Disorders of calcium homeostasis in the fetus and neonate.
MedLine Citation:
PMID:  7041784     Owner:  NLM     Status:  MEDLINE    
The physiological mechanisms involved in the alterations in calcium homeostasis during pregnancy are complex. The fetal acquisition of calcium, for skeletal growth, is obtained by an increase in intestinal calcium absorption in the mother with transplacental calcium transfer to the fetus. The regulation of calcium homeostasis during the transition from the intrauterine to the extrauterine environment is complex and poorly understood. Within the first few hours of life the serum calcium concentrations begins to fall progressively reaching a "trough" value by the second or third day of life and then increases to normal values by the tenth day of life. In some neonates the fall in calcium concentration is sufficient to be associated with either tetany or convulsions. Hypocalcemia is probably the commonest disturbance of calcium homeostasis that occurs in the neonate and can be subdivided into three main groups on the basis of the etiological mechanism involved. Other disorders of calcium homeostasis that may affect the neonate include hypoparathyroidism, either congenital or acquired, pseudohypoparathyroidism, and vitamin D deficiency. Hypercalcemia may occur, but is a relatively rare occurrence in the neonate.
M R Wills; D E Bruns; J Savory
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  12     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:    1982 Mar-Apr
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-88     Citation Subset:  IM    
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MeSH Terms
Calcium / analysis
Fetal Diseases / etiology*
Hypercalcemia / etiology*
Hyperparathyroidism / complications,  congenital
Hypocalcemia / etiology*
Hypoparathyroidism / congenital,  etiology,  genetics
Hypophosphatasia / diagnosis
Infant, Newborn
Infant, Newborn, Diseases / etiology*
Magnesium Deficiency / complications
Maternal-Fetal Exchange
Milk / analysis
Pregnancy Complications / blood
Pseudohypoparathyroidism / physiopathology
Tetany / congenital,  etiology
Vitamin D Deficiency / complications
Reg. No./Substance:

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