| Disordered lipid metabolism and the pathogenesis of insulin resistance. | |
| | |
MedLine Citation:
|
PMID: 17429039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Here we review recent human studies exploring the mechanistic links between disorders of fatty acid/lipid metabolism and insulin resistance. As "mouse models of insulin resistance" were comprehensively reviewed in Physiological Reviews by Nandi et al. in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight. |
| | |
Authors:
|
David B Savage; Kitt Falk Petersen; Gerald I Shulman |
Related Documents
:
|
9949859 - Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, path... 12915999 - Metabolic profile in patients with benign prostate hyperplasia or prostate cancer and n... 18190429 - Chromium picolinate for insulin resistance in subjects with hiv disease: a pilot study. 12893459 - Acute ethanol-mediated insulin resistance in the rat: the role of ethanol oxidation. 19887029 - Insulin resistance in insulin-resistant and diabetic hamsters (mesocricetus auratus) is... 12728539 - Long-term cardiovascular effects of insulin sensitizer troglitazone on non-diabetic ind... 22267299 - Initiating a glucagon-like peptide-1 receptor agonist in the management of type 2 diabe... 22005339 - Metformin restores the correlation between serum-oxidized ldl and leptin levels in type... 16936599 - Feet first: a guide to diabetic foot services. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Physiological reviews Volume: 87 ISSN: 0031-9333 ISO Abbreviation: Physiol. Rev. Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-04-12 Completed Date: 2007-05-15 Revised Date: 2011-03-01 |
Medline Journal Info:
|
Nlm Unique ID: 0231714 Medline TA: Physiol Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 507-20 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536-8012, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
metabolism Animals Fatty Acids / pharmacology Glucose / metabolism Humans Insulin Resistance / physiology* Lipid Metabolism Disorders / physiopathology* Liver / chemistry, metabolism Magnetic Resonance Spectroscopy Muscles / chemistry, metabolism Obesity / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
M01-RR-00125/RR/NCRR NIH HHS; P01-DK-68829/DK/NIDDK NIH HHS; R01 AG023686-05/AG/NIA NIH HHS; R01-AG-23686/AG/NIA NIH HHS; R01-DK-40936/DK/NIDDK NIH HHS; R01-DK-49230/DK/NIDDK NIH HHS; U24-DK-59635/DK/NIDDK NIH HHS; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Calcium and arrhythmogenesis.
Next Document: Cardiac myocyte cell cycle control in development, disease, and regeneration.