Document Detail

Disorder of the saliva melatonin circadian rhythm in patients with Meniere's disease.
MedLine Citation:
PMID:  16542165     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Stress is involved in the development of symptoms of Meniere's disease (MD). Stress-related disease has been reported to be associated with disorders in the circadian rhythm of melatonin (MEL) which regulates that rhythm. We therefore investigated MEL circadian rhythm of patients with MD. PATIENTS AND METHODS: A comparison of 13 MD patients was made with age-matched controls. Saliva samples were collected every 3 h. A statistical analysis of the circadian rhythm of saliva MEL was performed for a circadian rhythm by the fit of a 24- and 12-h composite cosine model. In addition, we assessed the stress and depression status of the two groups. RESULTS: The rhythmic amplitude of MEL in the MD group was significantly lower than that in the control group (P < 0.05). The acrophase in the MD group was significantly earlier than that in the control group (P < 0.05). MD patients had significantly higher stress score and depression score than control subjects (P < 0.05). The amplitude in MD patients had no significant correlation with their otologic clinical data. CONCLUSIONS: These results suggest that MD patients have a MEL deficiency, which is related to their stress and depression status rather than the otologic pathological status of MD.
M Aoki; Y Yokota; T Hayashi; B Kuze; M Murai; K Mizuta; Y Ito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  113     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-05-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  IM    
Department of Otolaryngology, Gifu University Graduate School of Medicine, Gifu, Japan.
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MeSH Terms
Case-Control Studies
Circadian Rhythm / physiology*
Melatonin / metabolism*
Meniere Disease / metabolism*,  psychology
Middle Aged
Saliva / metabolism*
Sleep / physiology
Stress, Psychological / complications,  metabolism
Reg. No./Substance:

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