Document Detail


Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats.
MedLine Citation:
PMID:  22874759     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Proteinuria is considered to play an essential role in the progression of tubulointerstitial damage which causes end-stage renal disease (ESRD). Fatty acid-binding albumin are filtered through glomeruli and reabsorbed into the proximal tubular epithelial cells (PTECs). However, the role of fatty acid metabolism associated with albuminuria in developing tubulointerstitial damage remains unclear. Thus, the present study was designed to determine the changes of fatty acid metabolism in the nephrotic kidney. To induce nephrotic syndrome, Sprague-Dawley rats (SDR) and Nagase analbuminemic rats (NAR) with inherited hypoalbuminemia were treated with a single injection of puromycin aminonucleoside (PAN). In SDR, the PAN treatment induced massive proteinuria and albuminuria and caused the tubular damage, apoptosis and lipid accumulation in the PTECs. Among the enzymes for fatty acid metabolism the expressions of medium-chain acyl-CoA dehydrogenase (MCAD) and cytochrome P450 (CYP) 4A significantly decreased in the PTECs of the PAN-treated SDR. The expressions of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and estrogen-related receptor α (ERRα) also significantly decreased without change of the expression of peroxisome proliferator-activated receptor α (PPARα). In NAR, the PAN treatment induced proteinuria but not albuminuria and did not cause the tubular damage, apoptosis or lipid accumulation. The expression of MCAD, PGC-1α or ERRα did not change in the kidney cortex of the PAN-treated NAR, but the expression of CYP4A significantly decreased. These results indicate that massive albuminuria causes the tubular damage and lipid accumulation with the reduction of MCAD, CYP4A, PGC-1α and ERRα in the PTECs.
Authors:
Yoshikazu Muroya; Osamu Ito; Rong Rong; Kenta Takashima; Daisuke Ito; Pengyu Cao; Yasuhiro Nakamura; Kensuke Joh; Masahiro Kohzuki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  -     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Tohoku University Graduate School of Medicine.
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