Document Detail

Disopyramide for transient high-degree atrioventricular block in a young patient with a history of syncope.
MedLine Citation:
PMID:  18639779     Owner:  NLM     Status:  In-Process    
Although high-degree atrioventricular (AV) block in patients with a history of syncope usually requires pacemaker implantation, therapeutic strategies should also be considered. A 35-year-old man presented with complaints of palpitations, nausea and dysgeusia. Since aged 30, the patient had experienced three episodes of syncope. Holter monitoring showed transient high-degree AV block (up to 5:4 block) associated with nausea, eructation and dysgeusia irrelevant to posture as well as ventricular ectopic beats with palpitation. A head-up tilt test revealed neurally mediated vasodepression but electrophysiological study showed no abnormalities. These results indicated that his transient high-degree AV block was functional, and syncope would have been because of neurally mediated vasodepression, not bradycardia. After administration of disopyramide at 300 mg daily, the symptoms subsided and ventricular ectopic beats and AV block disappeared. He has been well for 20 months.
Yukoh Hirai; Hideya Yamamoto; Yukiko Nakano; Hiroshi Ogi; Shinji Kajiwara; Nobuoki Kohno
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Publication Detail:
Type:  Journal Article     Date:  2008-06-19
Journal Detail:
Title:  Journal of cardiology     Volume:  52     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  59-61     Citation Subset:  IM    
Department of Molecular and Internal Medicine, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
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