Document Detail

Disopyramide: a promising new approach to the medical treatment of the hypercyanotic spell complicating tetralogy of Fallot.
MedLine Citation:
PMID:  9856595     Owner:  NLM     Status:  MEDLINE    
Under continuous ECG and oxygen saturation (SpO2) monitoring, the following measurements were taken by Doppler echocardiography in 6 consecutive patients with tetralogy of Fallot (TF) before and after intravenous administration of disopyramide (2mg/kg): left ventricular shortening fraction (LVSF); peak velocities in the right ventricular outflow tract (RVOT); diastolic and systolic internal diameters of the right ventricular outflow tract (dRVOT, sRVOT); and systolic blood pressure. SpO2 increased (p<0.01) from 78 to 98 (89 +/- 7, mean +/- standard deviation)% to 86-99 (94 +/- 5)%. LVSF decreased (p<0.05) from 0.34-0.56 (0.42 +/- 0.08) to 0.22-0.54 (0.33 +/- 0.13). The systolic blood pressure fell slightly (p<0.05) from 68-92 (79 +/- 8) to 64-92 (71 +/- 11)mmHg. The sRVOT increased (p<0.05) from 2.1-4.8 (2.7 +/- 1.5)mm to 3.0-8.1 (4.9 +/- 2.4)mm, while RVOT peak velocity decreased (p<0.05) from 2.20-4.88 (3.70 +/- 0.97)m/sec to 2.05-4.07 (2.92 +/- 0.72)m/sec. Disopyramide alleviates hypoxia in patients of TF through its negative inotropic action on right ventricular outflow obstruction.
H Tomita; S Fuse; K Hatakeyama; M Suzuki; S Chiba
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  62     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  807-10     Citation Subset:  IM    
Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Child, Preschool
Cyanosis / drug therapy*,  etiology*,  physiopathology
Disopyramide / therapeutic use*
Echocardiography, Doppler
Heart Ventricles / ultrasonography
Tetralogy of Fallot / complications*,  physiopathology,  ultrasonography
Ventricular Function / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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