Document Detail


Disomic locus content mapping.
MedLine Citation:
PMID:  8108424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A linear genetic map may be constructed from segregation of markers in DNA fragments broken by radiation or shearing and/or incorporated into a vector: this is locus content mapping. Theory for monosomic locus content mapping is extended to disomy, making the phase of heterozygous markers informative for linkage and each clone potentially informative for every chromosome. Because there is no interference among breaks and phase may be reliable inferred for all heterozygous loci, multiple pairwise mapping is especially appropriate.
Authors:
N E Morton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  91     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-22     Completed Date:  1994-03-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1421-2     Citation Subset:  IM    
Affiliation:
Department of Child Health, University of Southampton, Princess Anne Hospital, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping / methods*
Heterozygote
Linkage (Genetics)
Models, Genetic*
Monosomy
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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