| Disinhibition of somatosensory and motor cortex in mitochondriopathy without myoclonus. | |
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MedLine Citation:
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PMID: 11336909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test electrophysiologically, if patients with mitochondriopathy but without evidence of myocloni have subclinical signs of disinhibition in motor and somatosensory cortices. METHODS: Two patients were studied and compared with age-matched control groups. RESULTS: In both patients, giant somatosensory evoked potentials after median nerve stimulation and a reduced intracortical inhibition tested by transcranial magnetic stimulation in a paired pulse paradigm indicated a dysfunction of inhibitory circuits in the motor as well as the somatosensory cortex. In addition, the somatosensory evoked 600 Hz activity recorded by magnetoencephalography was abolished. CONCLUSIONS: Patients with mitochondriopathy may suffer from a subclinical disturbance of inhibition in the sensorimotor cortex. The loss of 600 Hz activity indicates that these high-frequency oscillations could reflect the activity of inhibitory neurons in the somatosensory cortex. |
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Authors:
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J Liepert; J Haueisen; S Hegemann; C Weiller |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 112 ISSN: 1388-2457 ISO Abbreviation: Clin Neurophysiol Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-04 Completed Date: 2001-06-28 Revised Date: 2008-09-10 |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 917-22 Citation Subset: IM |
Affiliation:
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Department of Neurology, Friedrich Schiller University of Jena, Jena, Germany. liepert@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Electric Stimulation Evoked Potentials, Somatosensory / physiology* Female Humans Magnetics Magnetoencephalography Median Nerve / physiopathology* Middle Aged Mitochondrial Myopathies / genetics, physiopathology* Motor Cortex / physiology, physiopathology* Motor Neurons / physiology Myoclonus Reference Values Sensory Thresholds Somatosensory Cortex / physiology, physiopathology* |
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