Document Detail

Dishevelled is essential for neural connectivity and planar cell polarity in planarians.
MedLine Citation:
PMID:  21282632     Owner:  NLM     Status:  MEDLINE    
The Wingless/Integrated (Wnt) signaling pathway controls multiple events during development and homeostasis. It comprises multiple branches, mainly classified according to their dependence on β-catenin activation. The Wnt/β-catenin branch is essential for the establishment of the embryonic anteroposterior (AP) body axis throughout the phylogenetic tree. It is also required for AP axis establishment during planarian regeneration. Wnt/β-catenin-independent signaling encompasses several different pathways, of which the most extensively studied is the planar cell polarity (PCP) pathway, which is responsible for planar polarization of cell structures within an epithelial sheet. Dishevelled (Dvl) is the hub of Wnt signaling because it regulates and channels the Wnt signal into every branch. Here, we analyze the role of Schmidtea mediterranea Dvl homologs (Smed-dvl-1 and Smed-dvl-2) using gene silencing. We demonstrate that in addition to a role in AP axis specification, planarian Dvls are involved in at least two different β-catenin-independent processes. First, they are essential for neural connectivity through Smed-wnt5 signaling. Second, Smed-dvl-2, together with the S. mediterranea homologs of Van-Gogh (Vang) and Diversin (Div), is required for apical positioning of the basal bodies of epithelial cells. These data represent evidence not only of the function of the PCP network in lophotrocozoans but of the involvement of the PCP core elements Vang and Div in apical positioning of the cilia.
Maria Almuedo-Castillo; Emili Saló; Teresa Adell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-31
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-04-14     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2813-8     Citation Subset:  IM    
Department of Genetics and Institute of Biomedicine, University of Barcelona, E-08028 Barcelona, Catalonia, Spain.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/HQ141793;  HQ141794;  HQ141795;  HQ141796;  HQ141797
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MeSH Terms
Adaptor Proteins, Signal Transducing / genetics,  metabolism*
Amino Acid Sequence
Base Sequence
Body Patterning / physiology*
Brain / physiology*
Cell Polarity / physiology*
Cluster Analysis
In Situ Hybridization
Microscopy, Confocal
Microscopy, Electron
Molecular Sequence Data
Neurons / metabolism,  physiology*
Phosphoproteins / genetics,  metabolism*
Planarians / physiology*
RNA Interference
Sequence Analysis, DNA
Signal Transduction / physiology
Wnt Proteins / metabolism
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Phosphoproteins; 0/Wnt Proteins; 0/dishevelled proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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