Document Detail

Disentangling the effects of risk factors and clinical care on subnational variation in early neonatal mortality in the United States.
MedLine Citation:
PMID:  23166659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Between 1990 and 2010, the U.S ranking in neonatal mortality slipped from 29(th) to 45(th) among countries globally. Substantial subnational variation in newborn mortality also exists. Our objective is to measure the extent to which trends and subnational variation in early neonatal mortality reflect differences in the prevalence of risk factors (gestational age and birth weight) compared to differences in clinical care.
METHODS: Observational study using linked birth and death data for all births in the United States between 1996 and 2006. We examined health service area (HSA) level variation in the expected early neonatal mortality rate, based on gestational age (GA) and birth-weight (BW), and GA-BW adjusted mortality as a proxy for clinical care. We analyzed the relationship between selected health system indicators and GA-BW-adjusted mortality.
RESULTS: The early neonatal death (ENND) rate declined 12% between 1996 and 2006 (2.39 to 2.10 per 1000 live births). This occurred despite increases in risk factor prevalence. There was significant HSA-level variation in the expected ENND rate (Rate Ratio: 0.73-1.47) and the GA-BW adjusted rate (Rate ratio: 0.63-1.68). Accounting for preterm volume (defined as <34 weeks), the number of neonatologist and NICU beds, 25.2% and 58.7% of the HSA-level variance in outcomes was explained among all births and very low birth weight babies, respectively.
CONCLUSION: Improvements in mortality could be realized through the expansion or reallocation of clinical neonatal resources, particularly in HSAs with a high volume of preterm births; however, prevention of preterm births and low-birth weight babies has a greater potential to improve newborn survival in the United States.
Lahn D Straney; Stephen S Lim; Christopher J L Murray
Related Documents :
8489789 - Prediction of outcome of preterm infants with severe bronchopulmonary dysplasia.
23586179 - Evidence-based thermal care of low birthweight neonates. part one.
16061589 - Morphine administration and short-term pulmonary outcomes among ventilated preterm infa...
4028749 - Diagnosis and therapy of necrotizing tracheobronchitis in ventilated neonates.
6690199 - Incidence of aspiration in endotracheally intubated infants and children.
10908519 - Prophylactic doxapram for the prevention of morbidity and mortality in preterm infants ...
942239 - Phototherapy. short and long-term complications.
24901099 - Nutritional status of breast-fed and non-exclusively breast-fed infants from birth to a...
11322219 - The hellp syndrome: maternal and perinatal outcome.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-14
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-06     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e49399     Citation Subset:  IM    
Institute for Health Metrics and Evaluation, The Department of Global Health, University of Washington, Seattle, Washington, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Birth Weight / physiology*
Catchment Area (Health) / statistics & numerical data
Gestational Age*
Infant Care / statistics & numerical data*
Infant Mortality / trends*
Infant, Newborn
Models, Statistical*
Risk Factors
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An accessible method for implementing hierarchical models with spatio-temporal abundance data.
Next Document:  An approach for the identification of targets specific to bone metastasis using cancer genes interac...