| Disentangling the Associations Between Autistic-Like and Internalizing Traits: A Community Based Twin Study. | |
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MedLine Citation:
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PMID: 22161152 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Internalizing difficulties are prevalent in children with autism spectrum disorders (ASD), yet little is known about the underlying cause of this comorbidity. It is also unclear which types of autistic-like and internalizing difficulties are most strongly associated. The current study investigated the phenotypic and etiological associations between specific autistic-like traits and internalizing traits within a population-based sample. Parent-reported data were analyzed from 7,311 twin pairs at age 7 to 8 years. Structural equation modeling revealed distinguishable patterns of overlap between the three autistic-like traits (social difficulties, communication problems and repetitive/restricted behaviors) and four subtypes of internalizing traits (social anxiety, fears, generalized anxiety, negative affect). Although all phenotypic associations were modest (rph = 0.00-0.36), autistic-like communication impairments and repetitive/restricted behaviors correlated most strongly with generalized anxiety and negative affect both phenotypically and genetically. Conversely, autistic-like social difficulties showed little overlap with internalizing behaviors. Disentangling these associations and their etiological underpinnings may help contribute to the conceptualization and diagnosis of 'comorbidity' within ASD and internalizing disorders. |
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Authors:
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Victoria Hallett; Angelica Ronald; Fruhling Rijsdijk; Francesca Happé |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-10 |
Journal Detail:
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Title: Journal of abnormal child psychology Volume: - ISSN: 1573-2835 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364547 Medline TA: J Abnorm Child Psychol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Yale University, Child Study Center, Suite 6b. 40 Temple Street, New Haven, CT, 06510-2715, USA, victoria.hallett@yale.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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