| Diseases associated with asbestos exposure. Diagnostic perspectives in forensic pathology. | |
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MedLine Citation:
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PMID: 6837538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asbestos, a fibrous mineral, has unique physical and chemical properties, including resistance to heat, acids, and other chemicals; flexibility; and great tensile strength. The fibers subdivide into unit fibrils of molecular dimensions, resulting in a vast mineral surface area which has a direct bearing on its unusual features and its numerous applications. Its biological effects, which include fibrogenesis and carcinogenesis, may be related to the cellular reaction, to its large specific surface, or to the size and shape of the fibers. Its oncogenic action may be multiplied by other carcinogens, principally cigarette smoking. There is clinical, pathologic, and epidemiologic evidence that exposure to asbestos, following a long latent period, constitutes an important health hazard. Direct occupational exposure, followed by a long lapsed period after the initial exposure, is associated with pleural plaques and pleural effusion, pulmonary parenchymal fibrosis (asbestosis), pulmonary carcinoma, pleural and peritoneal mesothelioma, and other neoplasms. Indirect exposure may also entail an increased risk of lung disease or mesothelioma or both. Medicolegal investigation of suspected cases includes a lifetime occupational history, clinical history including smoking habits, radiological findings, clinical evidence of asbestosis, and may require detection of asbestos tissue burden. |
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Authors:
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T Ehrenreich; I J Selikoff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of forensic medicine and pathology Volume: 4 ISSN: 0195-7910 ISO Abbreviation: Am J Forensic Med Pathol Publication Date: 1983 Mar |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2011-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8108948 Medline TA: Am J Forensic Med Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asbestos
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adverse effects* Environmental Exposure* Forensic Medicine Humans Lung Neoplasms / diagnosis*, etiology, pathology Mesothelioma / diagnosis*, etiology, pathology Pleural Diseases / diagnosis*, etiology, pathology Pleural Neoplasms / diagnosis*, etiology, pathology |
| Chemical | |
Reg. No./Substance:
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1332-21-4/Asbestos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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