| Diseases affecting bone quality: beyond osteoporosis. | |
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MedLine Citation:
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PMID: 21107923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bone quantity, quality, and turnover contribute to whole bone strength. Although bone mineral density, or bone quantity, is associated with increased fracture risk, less is known about bone quality. Various conditions, including disorders of mineral homeostasis, disorders in bone remodeling, collagen disorders, and drugs, affect bone quality. QUESTIONS/PURPOSES: The objectives of this review are to (1) identify the conditions and diseases that could adversely affect bone quality besides osteoporosis, and (2) evaluate how these conditions influence bone quality. METHODS: We searched PubMed using the keywords "causes" combined with "secondary osteoporosis" or "fragility fracture." After identifying 20 disorders/conditions, we subsequently searched each condition to evaluate its effect on bone quality. RESULTS: Many disorders or conditions have an effect on bone metabolism, leading to fragility fractures. These disorders include abnormalities that disrupt mineral homeostasis, lead to an alteration of the mineralization process, and ultimately reduce bone strength. The balance between bone formation and resorption is also essential to prevent microdamage accumulation and maintain proper material and structural integrity of the bone. As a result, diseases that alter the bone turnover process lead to a reduction of bone strength. Because Type I collagen is the most abundant protein found in bone, defects in Type I collagen can result in alterations of material property, ultimately leading to fragility fractures. Additionally, some medications can adversely affect bone. CONCLUSIONS: Recognizing these conditions and diseases and understanding their etiology and pathogenesis is crucial for patient care and maintaining overall bone health. |
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Authors:
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Aasis Unnanuntana; Brian J Rebolledo; M Michael Khair; Edward F DiCarlo; Joseph M Lane |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical orthopaedics and related research Volume: 469 ISSN: 1528-1132 ISO Abbreviation: Clin. Orthop. Relat. Res. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-30 Completed Date: 2011-09-30 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 0075674 Medline TA: Clin Orthop Relat Res Country: United States |
Other Details:
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Languages: eng Pagination: 2194-206 Citation Subset: AIM; IM |
Affiliation:
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Department of Orthopaedic Surgery, Hospital for Special Surgery, and Weill Cornell Medical College, Cornell University, 535 East 70th Street, New York, NY 10021, USA. uaasis@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antirheumatic Agents
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therapeutic use Bone Density* Bone Diseases / metabolism, physiopathology* Bone Resorption / physiopathology Bone and Bones / drug effects, metabolism, physiopathology* Collagen Diseases / physiopathology Fractures, Bone / physiopathology Glucocorticoids / therapeutic use Homeostasis / physiology Humans Hyperparathyroidism / physiopathology Osteopetrosis / physiopathology Osteoporosis / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents; 0/Glucocorticoids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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