Document Detail


Disease severity and knee extensor force in knee osteoarthritis: data from the Osteoarthritis Initiative.
MedLine Citation:
PMID:  22238225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the method of disease severity measurement influences the magnitude of knee extensor force deficits in knee osteoarthritis (OA).
METHODS: Data from the Osteoarthritis Initiative (n = 659) were analyzed. Knee extensor force was assessed with isometric contractions. Clinical severity was measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Patients were stratified into tertiles of severity (i.e., moderate, mild, and severe OA) based on the lowest, middle, and highest WOMAC scores, respectively. Kellgren/Lawrence (K/L) grading was used to assess radiographic severity of the tibiofemoral compartment and patients were again stratified into mild (K/L grade <2), moderate (K/L grade 2), and severe (K/L grade >2) knee OA.
RESULTS: When stratifying with the WOMAC, force was significantly lower in the severe group compared to the mild (~18% lower; P < 0.001) and moderate groups (~9% lower; P = 0.03), and in the moderate group compared to the mild group (∼10% lower; P = 0.03). When stratifying with K/L grade, small nonsignificant differences were observed in the severe (~7% lower; P = 0.19) and moderate groups (~8% lower; P = 0.08) compared to the mild group. Large intragroup variability was observed when comparing WOMAC scores across radiographic severity (coefficients of variation were 79.3%, 74.6%, and 61.6% for K/L grade <2, K/L grade 2, and K/L grade >2, respectively).
CONCLUSION: The method of disease severity stratification influences the magnitude of knee extensor force deficits because no difference in force between disease subgroups was observed when stratifying with K/L grade. Furthermore, there was large variability in the WOMAC score within each radiographic subgroup, highlighting the limitations in using radiographic measures to reflect symptom severity.
Authors:
Michael J Berger; Crystal O Kean; Aashish Goela; Timothy J Doherty
Related Documents :
22212965 - One thousand patients with primary myelofibrosis: the mayo clinic experience.
22258155 - Robot-assisted gait training in patients with parkinson disease: a randomized controlle...
22130355 - Little clinical advantage of computer-assisted navigation over conventional instrumenta...
21944115 - Open retropubic reanastomosis for highly recurrent and complex bladder neck stenosis.
15288975 - Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials ...
2734405 - Capillary hemangioma (strawberry mark) of infancy: comparison of argon and nd:yag laser...
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis care & research     Volume:  64     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-05-17     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. mberger2@uwo.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cohort Studies
Cross-Cultural Comparison
Female
Humans
Knee Joint / physiopathology*,  radiography*
Longitudinal Studies
Male
Middle Aged
Muscle Contraction / physiology*
Osteoarthritis, Knee / ethnology,  physiopathology*,  radiography*
Severity of Illness Index*
Grant Support
ID/Acronym/Agency:
N01 AR022258/AR/NIAMS NIH HHS; N01 AR022259/AR/NIAMS NIH HHS; N01 AR022260/AR/NIAMS NIH HHS; N01 AR022261/AR/NIAMS NIH HHS; N01 AR022262/AR/NIAMS NIH HHS; N01-AR-2-2258/AR/NIAMS NIH HHS; N01-AR-2-2259/AR/NIAMS NIH HHS; N01-AR-2-2260/AR/NIAMS NIH HHS; N01-AR-2-2261/AR/NIAMS NIH HHS; N01-AR-2-2262/AR/NIAMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The impact of CRISPR repeat sequence on structures of a Cas6 protein-RNA complex.
Next Document:  Scavenging of hydroxyl radical by catecholamines.