| Disease patterns at arterial branches and their relation to flow. | |
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MedLine Citation:
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PMID: 12122277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of lesions around arterial branch points is complex and changes with age. Four distinct patterns - here termed the arrowhead pattern, the lateral pattern, the upstream streak and the volcano - have been reported around the origins of intercostal arteries in the human aorta at different ages. The first two patterns also occur in young and old rabbits, the third in minipigs, and the fourth in apolipoprotein E/LDL receptor knockout mice. It is unclear how all four patterns can depend solely on flow; a particular problem is that the prevalence of lipid deposition remains highly nonuniform for several branch diameters upstream of the ostium. Variations in the prevalence of fatty streaks may originate near the branch and then spread by the migration of activated endothelial cells towards the heart. The pattern of raised lesions may reflect a different aetiology. |
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Authors:
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Peter D Weinberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biorheology Volume: 39 ISSN: 0006-355X ISO Abbreviation: Biorheology Publication Date: 2002 |
Date Detail:
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Created Date: 2002-07-17 Completed Date: 2002-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372526 Medline TA: Biorheology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 533-7 Citation Subset: IM |
Affiliation:
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School of Animal and Microbial Sciences, University of Reading, Reading, UK. p.d.weinberg@reading.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Aorta / pathology*, physiopathology Apolipoproteins E / genetics Arteriosclerosis / pathology*, physiopathology Child Columbidae Endothelium, Vascular / pathology* Humans Mice Mice, Knockout Models, Animal Rabbits Receptors, LDL / genetics Regional Blood Flow Swine, Miniature |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Receptors, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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