| Disease expression and class II HLA antigens in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 10483016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this investigation was to examine the relationship between Class II HLA antigens and disease expression in systemic lupus erythematosus (SLE). HLA-DR and DQ antigen frequency was studied serologically in 217 SLE patients followed prospectively and compared to 320 healthy controls. The relationship between HLA antigens and the presence of disease manifestations, as well as death was investigated in 117 SLE patients enrolled within the first year of their disease. A univariate analysis confirmed the association between HLA-DR3 and SLE. HLA antigen DR1, DR6, DR7, DQw1 and DQw3 were decreased in patient group compared to the controls. A logistic regression model showed a significantly negative association with HLA-DR1, DR6 and DR7, and a positive association with HLA-DR3. The reduced frequency of HLA-DQw1 and DQw3 was maintained using a logistic procedure. Cox Proportional Hazards models revealed no association between HLA-Class II antigens and death. Logistic regression models revealed no associations between central nervous system (CNS) disease nor musculoskeletal manifestations with any of the DR antigens. There was a trend towards a lower frequency of HLA-DR6 in patients with renal involvement and lower prevalence of HLA-DR1 and HLA-DR7 in patients with vasculitis. |
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Authors:
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D D Gladman; M B Urowitz; G A Darlington |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lupus Volume: 8 ISSN: 0961-2033 ISO Abbreviation: Lupus Publication Date: 1999 |
Date Detail:
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Created Date: 1999-11-02 Completed Date: 1999-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 466-70 Citation Subset: IM |
Affiliation:
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The University of Toronto, Centre for Prognosis Studies in the Rheumatic Diseases, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Female Histocompatibility Antigens Class II / immunology* Humans Lupus Erythematosus, Systemic / immunology*, physiopathology Male Middle Aged Prognosis Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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