Document Detail

Disease entities, mixed multi-normal distributions, and the role of the hyperkinetic state in the pathogenesis of hypertension.
MedLine Citation:
PMID:  2343223     Owner:  NLM     Status:  MEDLINE    
This paper concerns the theory and relevance of finite mixtures of univariate and multivariate normal distributions in medical research and suggests that multivariate normal mixture analysis, hitherto not extensively explored, is an appealing approach to the investigation of etiologically obscure, multifactorial diseases such as hypertension. We elaborate a statistical strategy to resolve and test for a normal mixture distribution in a seemingly heterogenous population actually comprising homogenous subpopulations. We use this strategy to validate the hypothesis that in the population at large there is a subgroup of individuals with the characteristic of a hyperkinetic circulatory state, defined as the association of an elevated cardiac index or heart rate with high blood pressure. This subgroup may have implications for the pathogenesis of hypertension. We discuss directions and implications for future research into the pathogenesis of hypertension.
N J Schork; A B Weder; M A Schork; D R Bassett; S Julius
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Statistics in medicine     Volume:  9     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-06-26     Completed Date:  1990-06-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  301-14     Citation Subset:  IM    
University of Michigan, Ann Arbor 48109.
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MeSH Terms
Cluster Analysis
Data Interpretation, Statistical*
Hypertension / diagnosis,  etiology,  physiopathology*
Models, Cardiovascular*
Multivariate Analysis
Normal Distribution

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