Document Detail

Disease distribution of beta 2-glycoprotein I-dependent anticardiolipin antibodies in rheumatic diseases.
MedLine Citation:
PMID:  7757107     Owner:  NLM     Status:  MEDLINE    
We investigated the clinical significance of IgG beta 2-glycoprotein I (GPI)-dependent anticardiolipin antibodies (aCL) in rheumatic diseases. Three hundred and seventeen patients were entered. They consisted of 133 patients with SLE, 60 with RA, 45 with SSc, 37 with PM, 23 with overlap syndrome (overlap), and 19 with unclassified connective tissue disease (UCTD). IgG beta 2-GPI-dependent aCL were examined by ELISA. While IgG beta 2-GPI-dependent aCL were detected in 13% of patients with SLE, these aCL were positive in two patients with SSc, two with overlap and 14 with UCTD. A significant association between IgG beta 2-GPI-dependent aCL and thrombosis was found. Clinical manifestations were studied in 32 patients with secondary APS based on SLE and 14 with primary APS (PAPS). Incidence of malar rash, arthritis, renal disorder, leucopenia, immunological disorders and hypocomplementemia were significantly less frequent in patients with PAPS. IgG beta 2-GPI-dependent aCL were detected in all patients with PAPS and in 34% of secondary APS. This difference was significant. These data suggest that IgG beta 2-dependent aCL are useful for identifying a subset in patients with APS.
J Kaburaki; M Kuwana; M Yamamoto; S Kawai; E Matsuura; Y Ikeda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lupus     Volume:  4 Suppl 1     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-29     Completed Date:  1995-06-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S27-31     Citation Subset:  IM    
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Antibodies, Anticardiolipin / blood,  immunology*
Antiphospholipid Syndrome / blood,  immunology*
Arthritis, Rheumatoid / blood,  immunology*
Connective Tissue Diseases / blood,  immunology
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Glycoproteins / blood*,  immunology
Immunoglobulin G / blood*
Lupus Erythematosus, Systemic / blood,  immunology*
Middle Aged
Retrospective Studies
beta 2-Glycoprotein I
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Glycoproteins; 0/Immunoglobulin G; 0/beta 2-Glycoprotein I

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