| Disease Extent ≥4 cm Is a Prognostic Marker of Local Recurrence in T1-2 Breast Cancer. | |
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MedLine Citation:
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PMID: 21845209 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Despite improvements of the therapy for breast cancer, a proportion of the patients still get local recurrence. The status of the surgical margins is the most often used parameter for decision regarding additional treatment. However, a negative margin is not a guarantee that there is not residual cancer left in the breast; additional parameters are needed to better predict the risk of local recurrence. The disease extent was evaluated in the surgical specimen from 313 women after breast-conserving therapy using large-section histology and was correlated to the incidence of local recurrence. A disease extent ≥4 cm was shown to be an independent marker for local recurrence; the cumulative 10-year local relapse rate for the group with a disease extent ≥4 cm was 20.5%, and for the rest 6.7%. We conclude that disease extent ≥4 cm seems to be an important factor when evaluating the risk for local recurrence. |
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Authors:
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D Lindquist; D Hellberg; T Tot |
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Publication Detail:
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Type: Journal Article Date: 2011-08-10 |
Journal Detail:
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Title: Pathology research international Volume: 2011 ISSN: 2042-003X ISO Abbreviation: Patholog Res Int Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101526292 Medline TA: Patholog Res Int Country: United States |
Other Details:
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Languages: eng Pagination: 860584 Citation Subset: - |
Affiliation:
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Department of Pathology and Clinical Cytology, Central Hospital Falun, SE-791 82 Falun, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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