Document Detail

Disease Characteristics in Non-Erosive Reflux Disease with and without Endoscopically Minimal Change Esophagitis: Are They Different?
MedLine Citation:
PMID:  22156539     Owner:  NLM     Status:  Publisher    
Background/Aims: The majority of patients with gastroesophageal reflux disease (GERD) appear to have non-erosive reflux disease (NERD). NERD may include minimal change esophagitis (MCE) and no endoscopic abnormalities (MCE-). We aimed to determine whether intraesophageal acid reflux as well as esophageal motility differed between patients with and without MCE. Methods: Consecutive patients with classic reflux symptoms were enrolled in the study. Patients without any mucosal injury were considered to be MCE-. Esophageal acid exposure as well as intragastric pH (<4) was determined by dual-channel ambulatory 24-hour pH monitoring. Results: A total of 100 patients (MCE-, 52 patients; MCE, 48 patients) were studied. The percentage of effective peristalsis was found similar between patients with and without MCE (p = NS). Esophageal acid contact as well as the DeMeester score did not differ between the groups (p = NS). The prevalence of positive symptom index was greater in MCE- patients than in MCE patients (p = 0.001). Intragastric acidity (pH <4) was similar between MCE- and MCE groups (p = NS). Conclusions: NERD, regardless of the presence of MCE, might exhibit similar disease characteristics in terms of esophageal acid exposure and motor dysfunction.
Wei-Yi Lei; Tso-Tsai Liu; Chih-Hsun Yi; Chien-Lin Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-13
Journal Detail:
Title:  Digestion     Volume:  85     ISSN:  1421-9867     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  27-32     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Department of Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
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