| Behçet's disease (Adamantiades-Behçet's disease). | |
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MedLine Citation:
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PMID: 21052488 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oral streptococci mediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues. Bes-1 gene encoded partial S. sanguinis genome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage. |
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Authors:
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Fumio Kaneko; Ari Togashi; Sanae Saito; Hideo Sakuma; Noritaka Oyama; Koichiro Nakamura; Kenji Yokota; Keiji Oguma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-01 |
Journal Detail:
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Title: Clinical & developmental immunology Volume: 2011 ISSN: 1740-2530 ISO Abbreviation: Clin. Dev. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101183692 Medline TA: Clin Dev Immunol Country: England |
Other Details:
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Languages: eng Pagination: 681956 Citation Subset: IM |
Affiliation:
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Institute of Dermato-Immunology and Allergy, Southern TOHOKU Research Institute for Neuroscience, 7-115 Yatsuyamada, Koriyama, Fukushima 963-8563, Japan. f.kaneko@mt.strins.or.jp |
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