Document Detail


Discriminative stimulus properties of histamine H1-antagonists in animals trained to discriminate d-amphetamine or pentobarbital.
MedLine Citation:
PMID:  2570867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pigeons were trained to discriminate i.m. administered d-amphetamine (AMPH) or pentobarbital (PB) from saline with responding maintained under a fixed-ratio 30 schedule of food delivery. Rhesus monkeys were trained to discriminate intragastrically administered AMPH or PB from saline using a signaled shock-avoidance trial procedure. In AMPH-trained pigeons the histamine H1-antagonists tripelennamine, diphenhydramine and chlorpheniramine consistently produced greater than 80% AMPH-appropriate responding. Pyrilamine substituted for AMPH in two of three pigeons. In contrast, chlorcyclizine, hydroxyzine, promethazine and the histamine H2-antagonist cimetidine all failed to produce AMPH-appropriate responding. None of the histamine H1-antagonists tested substituted for PB in PB-trained pigeons. In AMPH-trained monkeys, only tripelennamine completely substituted for AMPH. Whereas chlorpheniramine, diphenhydramine and pyrilamine did not produce AMPH-appropriate responding in monkeys, these compounds did produce observable excitation and convulsions. As with the PB-trained pigeons, none of the histamine H1-antagonists tested substituted for PB in monkeys. The results of the present study demonstrate that histamine H1-antagonists have differential discriminative stimulus properties in both pigeons and monkeys. Specifically, histamine H1-antagonists known to produce more central nervous system stimulation in humans share discriminative stimulus properties with AMPH and/or produce observable signs of stimulation in monkeys.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S M Evans; C E Johanson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  250     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-17     Completed Date:  1989-10-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  779-87     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Pritzker School of Medicine, University of Chicago, Illinois.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Columbidae
Dextroamphetamine / pharmacology
Dose-Response Relationship, Drug
Histamine H1 Antagonists / classification*,  pharmacology
Macaca mulatta
Pentobarbital / pharmacology
Species Specificity
Grant Support
ID/Acronym/Agency:
DA 00250/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Histamine H1 Antagonists; 51-64-9/Dextroamphetamine; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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